An unsuccessful search for disulfane (hydrogen disulfide, HSSH) toward the low-mass protostar IRAS 26293-2422 was reported in 2016 by Martín-Doménech and co-workers. The observations were made in 2013 with the APEX 12m telescope located at the Lllano de Chajnantor Observatory in Chile, where ALMA also resides. Martín-Doménech et al. also unusuccessfully sought the related species S₂H and S₂ toward IRAS 26293-2422; S₂H was subsequently detected toward the Horsehead Nebula in 2017.

The search for HSSH was based on spectroscopy measurements by Behrend and co-workers with additional measurements by Belov et al. and Yamada et al.. Theoretical studies include work by Herbst et al., Ye et al., and Palmer et al. Santos and co-workers performed experimental studies of the formation of HSSH and other sulfur compounds in ice. Fortenberry & Francisco theoretically characterized the related ion, HSSH⁺.